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Phase 2 trials used once-weekly subcutaneous injections ranging from 1 mg to 12 mg, with higher doses associated with greater weight reduction but more gastrointestinal side effects
In the previously discussed KC model, exenatide treatment increased ductal cell proliferation as compared to control mice 18
Participants had an average age of about 65 years and were followed for up to three years after initiating treatment
They therefore could not be sure if it was identical to the human GLP-1 sequence documented by Bell
In future, the researchers may use the information listed in this review as a clue to deeply understand the bioactive compounds in these herbal medicines for alleviating APAP-induced hepatoxicity, and their mechanisms of action
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