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In this way, the "liver filter" is skipped and the first-pass metabolism that usually occurs in the liver is avoided, which deactivates a large part of the Glutathione molecule, making it less functional and effective

Reference Module in Biomedical Sciences Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA

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Vascular Dysfunction : Compromise of the blood-brain barrier integrity leads to impaired nutrient and oxygen supply, contributing to neuronal dysfunction