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Sinus tarsi syndrome can be extremely uncomfortable, but its usually a temporary issue
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Patients with cancer history, autoimmune conditions, pregnancy, severe cardiovascular issues, or known peptide sensitivities should not use this therapy
The pattern across the timeline is that tolerability improves as effect accrues the roughest GI window is early, precisely when weight change is smallest, and by the time therapeutic doses are driving measurable change the gut has usually adapted to each step
2000, 33: S47-58
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