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4.1 The ApelinAPJ axis Apelin was identified as the endogenous ligand for the APJ receptor, a G proteincoupled receptor structurally related to the angiotensin II type 1 receptor but functionally distinct from the reninangiotensin system ( Despite these favorable metabolic effects, enthusiasm for apelin-based therapeutics waned due to its potent cardiovascular actions, including vasodilation and positive inotropy
Diabetes 54, 2988-2994
Risk factors include immobility, certain medical conditions, dehydration, smoking, obesity, and some medications
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