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Caldwell, A

Weeks 1-4: 2.5 mg once weekly Weeks 58 : 5 mg once weekly Weeks 912 : 7.5 mg once weekly if you can tolerate the previous dosage and further glycemic control is needed Weeks 1316 : 10 mg once weekly, if you have still not reached your target blood sugar levels Weeks 1720 : 12.5 mg once weekly, if needed Week 20 and onwards : 15 mg once weekly, which is the maximum dosage of Mounjaro If you experience side effects, your doctor may delay dosage escalation for the next 4 weeks or lower the dosage of Mounajro

Brand-Name Costs (Without Insurance): Monthly List Prices: Wegovy (semaglutide): $1,349 Ozempic (semaglutide): $969 Zepbound (tirzepatide): $1,069 Mounjaro (tirzepatide): $1,069 Saxenda (liraglutide): $1,400 Annual Costs: Semaglutide: $11,628-$16,188/year Tirzepatide: $12,828/year For 18-month treatment: $17,442-$24,282 These prices are unsustainable for most cash-pay patients

Other ingredients: L-carnitine

Limitations of Current Evidence Several significant limitations in the current evidence base warrant acknowledgment: Population Diversity : Most major trials have been conducted in predominantly white, well-resourced populations, potentially limiting generalizability to more diverse demographic groups where obesity prevalence is often highest