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and (2) forms of vitamin E other than -tocopherol are actively metabolized and excreted

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Upon challenge by oxidants Nrf2 does not undergo ubiquitination and is released from Keap1 as a result of the modification of cysteine residues in Keap1 and/or phosphorylation of Nrf2

In addition, plasma may have a low glutathione content and may be difficult to measure