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Failing to slow disease Progression of disease was measured by the change in Clinical Dementia Rating Sum of Boxes (CDR-SB) score and compared to placebo on top of standard of care
In a phase II dose-finding study, oral semaglutide doses of 2.5 mg to 40 mg co-formulated with 300 mg SNAC improved glycemic control, with a dose-dependent mean reduction in HbA 1c of up to 1.9% versus 0.3% for placebo, from a mean HbA 1c level of 7.9% (standard deviation: 0.7%) [59]
Typically, the first few months see the most dramatic drops as the body adjusts
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Clinical trials lasted 48-68 weeks, with ongoing weight loss throughout
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