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They eat less because they no longer enjoy it, and lose weight from the simple loss of caloric intake
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Metformin is the first line of treatment in newly discovered T2D patients and was first demonstrated to influence gut microbiota composition in diet induced obese mouse models, where it resulted in enrichment of Akkermansia muciniphila (39, 40), a gut commensal showing beneficial effects on metabolism (41)
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Gnoni, A., Longo, S., Gnoni, G
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