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The most well-known tumor-homing peptide is the RGD peptide, including RGD4C (ACDCRGDCFCG) and Cilengitide (RGDfV), which bind to overexpressed v3 integrin in the angiogenic endothelial cells of tumor blood vessels, thereby inhibiting angiogenesis 9,10,11

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By influencing this pathway, KPV is examined in contexts where persistent signaling activity may affect cellular stability and tissue environment