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This made it less practical for research designs that benefited from sustained or once-weekly exposure profiles

TRIUMPH-4 didn't specifically study patients with established cardiovascular disease, but TRIUMPH-3 is evaluating retatrutide in this population with results expected in 2026

This intermittent approach can work when paired with strong lifestyle practices during off periods

Your body defends against further weight loss through reduced energy expenditure, increased hunger signaling (though still suppressed by medication), and improved metabolic efficiency

Persistent or worsening symptoms beyond this period warrant medical review to identify underlying causes