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With respect to possible enforcement of this policy, in FDAs press release FDA clarifies policies for compounders as national GLP-1 supply begins to stabilize issued on October 2, FDA stated: FDA reminds compounders of the legal restrictions on making copies of FDA-approved drugs. This language suggests that FDA, in conjunction of with state Boards of Pharmacy may pursue enforcement action against compounders that continue to compound with this ingredient and possibly related combinations outside of the guidance and exemptions noted above

Using a health economic microsimulation model to project lifetime costs, quality-adjusted life years (QALYs), and the burden of cardiovascular and renal comorbidities for this high-risk patient group, the investigators examined how the cost-effectiveness of GLP-1RAs changes across a range of possible prices

The most common side effects are nausea, vomiting, diarrhea, and constipation

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