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For someone with obesity, the cardiovascular risk reduction from losing 25% of their body weight almost certainly exceeds the risk from a 5 to 10 beat per minute resting heart rate increase

This suggests that long-term or potentially indefinite use may be necessary for sustained results

10 :1327 doi: 10.3389/fphys.2019.01327 6

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Thrainsdottir IS, Aspelund T, Thorgeirsson G, Gudnason V, Hardarson T, Malmberg K, Sigurdsson G, Ryden L