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152 Additionally, cleavage to form the active drug may not occur at a sufficient rate and with the necessary accuracy to produce localized therapeutic concentrations of the drug
For deficiency correction, weekly injections are often recommended for an initial period, followed by monthly maintenance
3.3 Treatment strategies Calcium channel blockers, such as amlodipine, have shown promise in preventing cocaine-induced vascular toxicity by lowering blood pressure and reducing headache frequency (Malcolm et al., 2002
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