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Retatrutide, a GIP/GLP-1/glucagon receptor triagonist for obesity
The Zepbound injection can cost $300-$450 per month through LillyDirect without insurance, versus $150-$350 a month for Foundayo, USA TODAY previously reported
They stimulate glucose-dependent insulin release from the pancreas, slow gastric emptying (prolonging a feeling of satiety), inhibit post-meal glucagon release (glucagon stimulates liver and muscle cells to convert stored glycogen back into glucose, raising blood glucose levels) and reduce the desire for food intake
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