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Heart conditions Do not take amitriptyline if you have recently had a heart attack or have serious heart rhythm problems (such as heart block), as it can affect your heart rate and rhythm

Apr 1 1998;128(7):524-533

When used in conjunction with diet and exercise, it can cause significant weight loss, and possibly reduce risk of cancer, diabetes and heart disease in people who are overweight

Employers including JPMorgan Chase , Amazon , and Apple include GLP-1 obesity coverage in employee health plans

Naltrexone-bupropion combines opioid antagonism with dopamine and norepinephrine reuptake inhibition to modulate hunger and reward centers