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Pregnancy, severe kidney or liver impairment, adults over 75, and people with several health conditions at once are typically under-represented in trials
Mar 2015;58(3):596-603
They help us distinguish between a real effect and a placebo or random chance
For many individuals, meaningful benefit may require long-term or lifelong use, similar to other maintenance medications used in chronic conditions
10.1016/j.bmc.2018.01.006 44 DerosaG.MaffioliP.FerrariI.MereuR.RagonesiP
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