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Cells 2022;11:3635

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In virt del suo ruolo biologico, fondamentale nel: Facilitare l'ingresso degli acidi grassi a lunga catena all'interno dei mitocondri, dove vengono ossidati per produrre energia (dal punto di vista biochimico la Carnitina svolge le proprie funzioni partecipando ad un complesso meccanismo chiamato carnitina acil-CoA transferasi) Mantenere costante il rapporto AcetilCoA/CoA all'interno delle cellule ottimizzando la conversione del piruvato e del lattato ad AcetilCoA ed espletando contestualmente una indiretta azione antiossidante, soprattutto nei confronti di cellule ad alto metabolismo, come quelle cardiache e muscolari

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Glutathione is the master antioxidant but there are many other antioxidants which are helpful, including vitamin C, vitamin E, quercetin, beta glucans (eg from medicinal mushrooms), zinc, selenium, and others

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Taken together, these data confirm that the activity of UCK2 to restore UMP levels is the driving force behind increased PGC1mTOR-linked mitochondrial biogenesis to resolve pyrimidine stress when cells are treated with 5FU

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Despite decades of research, the etiology and pathophysiological mechanisms underlying SCZ remain poorly understood

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