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According to multiple meta-analyses, MTHFR C677T and A1298C increase the relative risk for high homocysteine, cardiovascular disease, stroke, neural tube defects, certain pregnancy issues, depression, migraines, and some neuropsychiatric conditions, especially with low folate/B vitamins.[ref] These same variants can lower the risk for certain conditions as well, illustrating tradeoffs of both positive and negative effects
Hyaluronic acid association with bacterial, fungal and viral infections: Can hyaluronic acid be used as an antimicrobial polymer for biomedical and pharmaceutical applications
Long-Term Risks of Vitamin B12 Overdose Persistent skin issues Nervous system irritation Blood pressure changes Increased cardiovascular stress excessive supplementation without medical oversight
PMID: 38205450 19 Megaloblastic Anemias: Nutritional and Other Causes
showed that the 16189 variant (T C transition) in mtDNA was associated with insulin resistance in Caucasians
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