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Both animal [76] and human [77] studies suggest that VPA-induced hyperammonaemia may be enhanced via renal rather than hepatic mechanisms
These trials have shown reductions in heart failure symptoms and physical limitations and greater improvement in exercise function and have led to growing interest in new ways to address HFpEF, a condition with limited guideline direct medication therapy compared to heart failure with reduced ejection fraction (HFrEF)
By Week 16, both groups had similar total improvement
(8 March 2023)
Inflammation of the pancreas is a serious but rare side effect
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