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The recent approval of nerandomilast, a selective inhibitor of PDE4 reducing the expression of inflammatory cytokines and pro-fibrotic growth factors, for the treatment of idiopathic pulmonary fibrosis (IPF) underlines the importance of targeting these two axes in fibrotic diseases [44, 45]
Patients should be advised to consume adequate protein (1.2-1.5 g/kg ideal body weight daily) and engage in resistance training
When these side effects are managed with vitamin B6, patients are more likely to stay on their prescribed dosing schedule, gradually increase to the optimal maintenance dose with less discomfort, and achieve their long-term weight loss goals
Doctors can help in other ways, but they don't have a pill or shot that's made just for this problem (1)
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