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Meng J, Zhang D, Pan J, Wang X, Zeng C, Zhu K, et al
Quantifying the global cellular thiol-disulfide status
Discontinuation rates due to adverse events were reported as low and single-digit across both REDEFINE 1 and 2, which Novo Nordisk highlighted as a positive tolerability signal given the drugs dual-mechanism approach
The most common issues are cosmetic and mild: transient stinging or redness, dryness, and occasionally a faint bluish or brownish tint on the skin from the copper, particularly at higher concentrations
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