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Dose escalation follows a gradual titration schedule to minimize gastrointestinal adverse effects, the most common being nausea, vomiting, and diarrhea

In contrast, tellurium-containing nanomicelles form stronger platinummetal bonds due to Tes higher metal affinity, enabling slower, sustained cisplatin release that prolongs therapeutic effects while minimizing systemic toxicity

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Conclusions Tirzepatide may be an effective treatment for older adults without obesity, and in this post hoc analysis, it was associated with clinically relevant HbA1c reduction and dose-proportional weight loss without increasing hypoglycemic risk