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Experiments in mice with neuronally confined macroautophagy-gene knockouts develop intraneuronal aggregates leading to neurodegeneration

used subcellular fractionation and imaging to confirm plasma membrane localisation and to demonstrate that myristoylation and flavin adenine dinucleotide (FAD)dependent oxidoreductase activity are both required for ferroptosis suppression, with nonmyristoylated or catalyticdead FSP1 variants failing to rescue ferroptosis despite comparable expression

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PMID 20923787