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Considering all these data together, it is reasonable to assume the existence of an RBC-Hb self-assembly system and a spontaneous system of drug release by RBCs after oral or intravenous administration of this drug, which provided a new understanding of the discrepancy between the high tissue concentration and extremely low plasma concentration of berberine

In a phase 2 clinical trial, CagriSema reduced HbA1c by 2.2% (p = 0.075) in comparison with semaglutide 2.4 mg alone [101]