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These changes in metabolism pathways were associated with a significant increase in 29 metabolites as shown in Supplementary Figure 11
Increased serum levels of TNF-, IL-6, and IL-1, released from disease-associated macrophages, were observed in patients with endometriosis-induced infertility (70, 71), creating a feedforward loop to aggravate endothelial cell activation
Clinical studies of CagriSema have measured endpoints such as body weight change, glycemic measures, and cardiometabolic risk markers in adults with overweight/obesity (including some with type 2 diabetes)
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