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45 times the current RDA) for two months was linked to improvements in self-reported mood, including the feeling of being more clear-headed (141)

Vitamin B12 is important for brain function, and a deficiency can lead to cognitive impairment, such as memory loss and difficulty concentrating

These findings highlighted that ultrahigh-dose methylcobalamin was efficacious in slowing functional decline in patients with early-stage ALS and with moderate progression rate and was safe to use during the 16-week treatment period, the researchers wrote

In some cases, modifiers like 50 may be used based on payer rules

A small randomized controlled trial found that application of 1% ajoene cream to the skin twice daily was as effective in treating tinea pedis (fungal skin infection known as athletes foot) as 1% terbinafine (Lamisil) cream (86)