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The equivalent residue is a serine or alanine in oxyntomodulin and GLP-1 respectively, contributing to a more stable -helical conformation, while also forming additional interactions at the base of the GLP-1R binding pocket (Figs
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Given their direct and indirect control of post-prandial nutrient uptake and demonstrated translational relevance for the treatment of type 2 diabetes, malabsorption and cardiometabolic disease, there is significant interest in the locally engaged circuits mediating these metabolic effects
Do not take it with fruit juices such as apple, orange, or grapefruit
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