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FIGURE 3 7.1 Neurotoxicity and cognitive impairments Heroin-induced oxidative stress disrupts the balance between oxidation and antioxidation (Xu et al., 2006), leading to neuronal death and BBB disruption during withdrawal (Sharma and Ali, 2006)
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This is supported by observations that women without preeclampsia who give birth to small for gestational age babies also exhibit low PlGF levels early in pregnancy (267)
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