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The gastrointestinal side effects commonly associated with tirzepatideincluding nausea, diarrhea, vomiting, and abdominal discomfortmay overlap with symptoms of celiac disease, particularly in patients with incomplete mucosal healing or inadvertent gluten exposure
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Nature 388 , 839840 (1997)
The strategic differentiation thesis that emerged from the analysis: CT-388 is best positioned as the "Balanced Precision Dual Agonist," differentiated from tirzepatide by equimolar GIP:GLP-1 engagement (1:1 vs 9:1), a distinct peptide scaffold with independent IP, and a five-year extended exclusivity window
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