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Blood pressure-related effects (low blood pressure, episodes of loss of consciousness), highlighting the need for careful monitoring
Alcohol is best avoided during dose titration, as it amplifies GI side effects and affects liver function
It is crucial to note, however, that recent studies highlight significant systemic side effects of MCT4 inhibition due to its broad tissue expression, which may limit its clinical translational potential and necessitate the development of tissue-specific delivery strategies [138]
However, RAS inhibition has not yet been found to prevent kidney disease among those with type 1 diabetes, normal blood pressure and without albuminuria, and also does not prevent the progression of histological changes associated with DKD at the early stage of disease [22]
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