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The dual mechanism offers a promising advantage over traditional GLP-1 RAs such as semaglutide , which is found in diabetes and weight management medications such as Ozempic and Wegovy
Overdosing drives side effects that reduce adherence and adherence, not peak dose, is the variable most predictive of long-term metabolic outcomes
This weight reduction contributes to improved cardiovascular risk profiles, as obesity is an independent risk factor for heart disease, stroke, and peripheral vascular disease
Adults with moderate overweight (BMI of 27 or greater) with at least one weight-related condition, such as type 2 diabetes, high cholesterol, or high blood pressure (hypertension)
The safety profile remains remarkably clean with minimal side effects reported across decades of use
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