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Metformin, a first-line T2DM treatment, affects the gastrointestinal tract by altering glucose uptake, GLP-1 secretion, gut microbiota, and immune response [33, 34], but it rarely causes bowel obstruction

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The few studies that have used those tools, including the Langer data, do not show disproportionate muscle loss

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Patients should receive written contact instructions and avoid driving when dizzy, faint, sedated, or otherwise impaired

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This study is, however, just the first step and Semenza emphasises that more work is needed

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