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Water retention increases temporarily, often in response to hormonal shifts or changes in sodium intake

Following a thorough analysis of our previous Phase IIb data and trial design, we are confident that with the preferred modified release formulation and optimized future trial design, we can advance a competitive oral GLP-1 molecule into registration-enabling studies to meet the ongoing medical needs of people living with obesity. The ongoing open-label, randomized study is assessing the pharmacokinetics and safety of immediate- and modified-release formulations of danuglipron administered orally in healthy adults aged 18 years or older

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Hexarelin binds to the CD36 receptor expressed on cardiomyocytes and the cardiac microvascular endothelium