The standard protocol from the SUSTAIN trials (Marso et al., New England Journal of Medicine , 2016): Reduce basal insulin dose by 20% on the day you start semaglutide Monitor fasting blood glucose daily for the first 2 weeks Further reduce basal insulin by 10 to 20% if fasting glucose drops below 80 mg/dL or if hypoglycemia occurs Reduce mealtime (bolus) insulin by 20 to 30% during semaglutide titration, adjusting based on post-meal glucose readings Most patients on basal insulin end up reducing total daily insulin dose by 30 to 50% by the time they reach maintenance semaglutide dose
Your results will depend on your starting weight, adherence to diet changes, and how your body responds to the medication
Maintenance Phase Many individuals who have achieved their weight loss goals opt to continue GLP-1 medications in a maintenance phase
GIP(1-42), K* denotes the acylated lysine, and NH 2 indicates C-terminal amidation
A structured approach, such as Nooms behavior change program, can help maintain long-term results