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Recently, Wang et al
Accessed: 2024-10-14
PubMed, doi:10.1016/j.scitotenv.2019.05.132
Combining with DPP-4 inhibitors is generally not recommended, as both drug classes work on the incretin system Adding basal insulin for those with more significant hyperglycaemia, which can be used alongside GLP-1 medications (with careful monitoring for hypoglycaemia) Switching to insulin therapy entirely may be necessary for those with advanced beta cell failure For weight management , when GLP-1 medications don't produce adequate weight loss, alternatives include: Orlistat , a lipase inhibitor that reduces fat absorption, though weight loss is typically modest (2-3 kg on average) Naltrexone-bupropion (Mysimba), which works on appetite centres through different pathways
GLP-1 RA Side Effects and Considerations GLP-1 drugs are generally well-tolerated, but like all medications, they may also have specific side effects and important considerations that you should be aware of 7 : Side Effects Gastrointestinal symptoms such as nausea, vomiting, and diarrhoea are the most common
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