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In a randomized controlled trial, 44 obese or overweight women treated with 80 mg of pyridoxine hydrochloride (a form of vitamin B6) for eight weeks experienced improved insulin sensitivity and decreased fat mass compared with placebo (Haidari 2021)
Translating animal doses to human equivalents requires consideration of species-specific pharmacokinetic differences
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Ann Intern Med 94:317321 Kramer HJ, Stinnesbeck B, Klautke G, Kipnowski J, Klingmueller D, Glaenzer K, Duesing R (1985) Interaction of renal prostaglandins with the renin-angiotensin and renal adrenergic nervous systems in healthy subjects during dietary changes in sodium intake
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