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Additionally, GHK-Cu appears to regulate the TGF-/SMAD pathway a critical pathway involved in fibrosis (pathological scarring of organs)

Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, et al

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Collagen gel contraction assays Fibroblast cultures at passage 3 were cultured in six-well tissue culture plates (Gibco, Canada) in growth medium (DMEM, 10% FBS, penicillin, and streptavidin from Invitrogen, Canada)

Epitope-tagged human FUS/TLS accumulated to a level equivalent to endogenous FUS/TLS in the parental cells, with a corresponding reduction in untagged endogenous FUS/TLS to about half its initial level, presumably through autoregulation (Fig