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Choline can be generated from phosphatidylcholine via phospholipases or converted to phosphatidylcholine via the cytidine diphospho-choline pathway (see Figure 2a)

The reduction of B

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50,51,52 Mechanistically, through HDAC inhibition, butyrate enhances the acetylation of the canonical nuclear factor kappa-light-chain enhancer of activated B cells (NF-B) subunit p65 and its differential recruitment to pro-inflammatory gene promoters, independent of nuclear translocation, or through protein kinase B (Akt)/mTOR/forkhead box O3a (FoxO3a) and F-box protein 32/tripartite motif-containing protein 63 (FBOX32/TRIM63) pathways