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Whilst vitamin B12 toxicity is exceptionally rare due to its water-soluble nature, very high levelsparticularly from mega-dose supplements or frequent injectionshave been associated with certain adverse effects, most notably skin reactions

Al bloquear el sitio activo de la enzima de forma permeable a membrana, 5-Amino-1MQ reduce la produccin de 1-MNA y preserva la nicotinamida disponible, lo que en modelos experimentales se asocia con restauracin de los niveles intracelulares de NAD+ y SAM