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A recent study investigated the effects of GLP-1R agonists in a multi-hit mouse model in which the combination of a high-fat diet and angiotensin II-induced a cardiometabolic HFpEF phenotype that resembles the human HFpEF phenotype to a large extent characterized by obesity, impaired glucose handling, and metabolic dysregulation accompanied by inflammation

18 It also helped the participants feel fuller for longer and supported blood sugar control

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Some healthcare providers may consider prescribing both medications simultaneously in select cases, particularly when patients have not achieved adequate weight loss with semaglutide alone or when attempting to transition from one medication to another