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Fig.4 Efficacy evaluation of semaglutide and tirzepatide in HFD+CCl 4 -Induced MASH Mouse Models A
The NDA submission was partly based on topline results from the ongoing single location BHV4157-206-RWE study (NCT06529146), in which troriluzole 200 mg administered orally once daily led to a 5070% slower rate of decline from baseline in the functional Scale for the Assessment and Rating of Ataxia (f-SARA) in all SCA genotypes at 3 years compared to an external control arm. Data from the BHV4157-206 study (NCT03701399) also demonstrated disease stabilization in the SCA3 genotype and a reduction in falls in all SCA genotypes compared to placebo over 48 weeks. If approved, troriluzole will be the first and only medication indicated for the treatment of SCA
Guo Q, Jin Y, Chen X, Ye X, Shen X, Lin M, et al
it has a large Vd and appears to be taken up into tissues
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