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The bioanalytical method based on liquid chromatography separation, mass spectrometry detection, and sample preparation exhibits good selectivity, high sensitivity, and wide linear range, making them widely used for the quantitative analysis of GLP-1 analogues in bioanalysis

Tirzepatide is the next-generation GLP-1 drug a dual-action peptide that targets both GLP-1 and GIP receptors and produces meaningfully greater weight loss than semaglutide in head-to-head trials

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Updated November 8, 2025

The choice depends on whether oral convenience or maximum proven efficacy is the priority