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It should be used cautiously or avoided in people with: Coronary artery disease Peripheral vascular disease (including ischemic bowel disease) History of heart attack or angina Wolff-Parkinson-White syndrome Uncontrolled high blood pressure (hypertension) Ibuprofen can also raise blood pressure in some people, particularly with frequent use or higher doses

Original publication: Rosenstock J, Allison D, Birkenfeld AL, Blicher TM, Deenadayalan S, Jacobsen JB, Serusclat P, Violante R, Watada H, Davies M

PMID 40005999

Optimization Phase (Months 2-3) The 8-12 week timeframe typically represents the period during which more substantial benefits become apparent