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There were fears that dosages over an upper tolerable limit may enhance the risk of kidney stones, iron toxicity, vitamin B12 deficiency, copper deficiency, dental enamel erosion, and diarrhoea, amongst others

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They also have broader metabolic effects, including improvements in cholesterol levels, reduced inflammation in fat tissue, and changes in where fat is stored

The editorial was published in the For decades, fatty liver disease and its more serious inflammatory form, metabolic dysfunction-associated steatohepatitis (MASH), were often overlooked conditions with few approved treatments

Many clients start with evening injection during dose escalation (sleep through worst symptoms) and switch to morning once they're stable on a maintenance dose