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In early-stage PD patients, somatic mtDNA point mutations are markedly elevated in SN dopaminergic neurons, with respiratory chain defects resulting from mtDNA deletions being particularly prominent (117, 118)

Over the years, a rising trend has been seen in the prevalence of depression since the time of observation (Cui et al., 2024)

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The question is whether the field is willing to slow down long enough to ask what its missing