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[1] [2] As a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, Zepbound works by mimicking naturally occurring incretin hormones that regulate appetite, food intake, and glucose metabolism, though the exact mechanism for weight loss is not fully understood

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A few studies in preclinical cell-based models have observed increased expression of neurogenesis-related markers through proposed epigenetic modulation mechanisms

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Given its biological effects, activation of GLP-1R has been explored as a latent treatment for metabolic disorders like type 2 diabetes mellitus (T2DM) and obesity