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When compared to their counterparts in normal controls, components of the expression of complex I-encoding genes were downregulated to differing degrees in both the IC-B and PEC compartments ( Figure 4D )
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Anthracycline-based FAC and FEC regimens demonstrate Level 1 evidence through Phase III trials, with GEICAM showing superior disease-free survival in 985 women and EBCTCG meta-analyses confirming 38% mortality reduction in women under 50 years, establishing it as adjuvant standard despite manageable cardiotoxicity