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This counteracting effect of L-carnitine was dose-dependent and statistically significant at least at 4 h of exposure (Figure 6)
We mentioned in our previous description that thiol oxidation is a common denominator in transcriptional regulation in the GPX family
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For example, mitochondrial muscle diseases cause NAD + deficiency, detectable both in the muscle and blood 15,16
Specifically, downregulated heat shock protein A12A (HSPA12A) in hepatocytes increases glycolysis and lactate production, which leads to HMGB1 lactylation and exosomal secretion of hepatocytes, exacerbating hepatocyte damagemacrophage chemotaxis/activation
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