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The development of rare adverse events, which may not occur until a patient has been on a drug for a number of years, is of concern, but until more patients are followed for an adequate period of time, the true safety of a drug cannot be stated or concluded
Epub 2017 Jun 26
Two points are specific to the blended format
dull complexion
The performance and financial cost of extended absence create motivation to explore off-label options despite regulatory and safety uncertainties
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