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Downstream of signaling pathways, transcription factors including FOXAs, GATA4/6, HNF4, and HNF1 interact with each other and activate liver-specific gene expression, accompanied by epigenetic changes
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Downstream signaling involves PI3K/AKT, MAPK/ERK, and PLC- pathways, which are well-characterized drivers of synaptogenesis, dendritic spine maturation, and neuronal survival